Which molecule is an endogenous lipid-based ligand for CB1 receptors?

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Multiple Choice

Which molecule is an endogenous lipid-based ligand for CB1 receptors?

Explanation:
Endocannabinoids include lipid-derived ligands that bind to CB1 receptors in the brain. Anandamide is one of these endogenous cannabinoids and is produced from membrane lipids in the postsynaptic neuron, then travels back across the synapse to activate CB1 receptors on the presynaptic terminal to modulate neurotransmitter release. This lipid-based, on-demand signaling distinguishes it from other neurotransmitters. The other substances listed—dopamine, glutamate, and GABA—are classic neurotransmitters (dopaminergic, glutamatergic, and GABAergic systems, respectively) and are not lipid-derived ligands for CB1 receptors.

Endocannabinoids include lipid-derived ligands that bind to CB1 receptors in the brain. Anandamide is one of these endogenous cannabinoids and is produced from membrane lipids in the postsynaptic neuron, then travels back across the synapse to activate CB1 receptors on the presynaptic terminal to modulate neurotransmitter release. This lipid-based, on-demand signaling distinguishes it from other neurotransmitters. The other substances listed—dopamine, glutamate, and GABA—are classic neurotransmitters (dopaminergic, glutamatergic, and GABAergic systems, respectively) and are not lipid-derived ligands for CB1 receptors.

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